Nose and ocular allergic symptoms usually precede and accompany immunological OA.
To see the full article, log in or purchase access. Curr Opin Allergy Clin Immunol 2010; 10: Get Permissions. The stepwise approach is meant to assist, not replace, the clinical decision making required to meet individual patient needs.
HMW allergens are also amenable to more detailed immunologic studies, such as electrophoretic methods in combination with immunoblotting, crossed radioimmunoelectrophoresis and other methods, that allow identification and characterization of the allergenic components.
Immunologic tests that measure IgE responses are valuable when integrated with other data. Several studies have been able to demonstrate the presence of exposure-sensitization and exposure-symptoms relationships to several occupational allergens 22.
When can personal best peak flow be determined for asthma action plans? Ann Allergy Asthma Immunol 2003; 90 5 suppl 2: Dual responses involve both early response with complete or near-complete recovery followed by a late phase. Some individuals can react positively on SPT and not demonstrate allergen-induced asthma.
Whenever feasible, SIC may be done relatively early in the diagnostic work-up. Nevertheless, whether sputum analysis is a useful tool in evaluating the integrated effect of inflammation on the functional and clinical consequences of OA is still unclear.
Progressive loss of lung function. Exposure to allergens or chemical sensitizers in the workplace often induces eosinophilic inflammation in sensitized subjects, although in some cases neutrophilia has been reported 15.
Specific questions on possible food allergy symptoms should be asked, since certain causative agents of OA may also cause food allergy after being ingested by some patients e. When the clinical history raises the suspicion of work-relatedness, further action should be taken.
Moreover, it has been reported that changes in both sputum eosinophil counts and bronchial responsiveness to methacholine are satisfactory predictors of a significant bronchial responsiveness to occupational agents in SIC 46.
Inhaled corticosteroids improve asthma control more effectively in children and adults than any other single long-term controller medication. National Heart Lung and Blood Institute; 2007 http: A study carried out in the USA showed that among adults with asthma treated in general practice settings, about 1 in 10 patients has a work history strongly suggestive of a potential relationship between exposure and disease 1.
Chemosensitivity and perception of dyspnea in patients with a history of near-fatal asthma. Classification of a patient's disease also depends on current impairment and future risk. FEV 1 or peak flow.