To combat residual stimulant effects, marijuana and benzodiazepines are often used.
Peak subjective intoxication correlates with peak MDMA plasma levels. After examining the laws and available literature and expert opinion, the judge concluded that MDMA met the criteria for being safe when used under medical supervision, had medical use, and was not highly addictive, and as such, could not legally be placed higher than Schedule 3.
Since then, usage levels have increased at a near-geometric rate, cheerfully indifferent to escalating penalties, from perhaps a few hundred thousand lifetime users pre-prohibition to 8.
Making MDMA synthesis. Abstract  2.
One group of extremely heavy MDMA users that had quite low SERT density a study championed as proof of MDMA neurotoxicity in humans by the US government were still within the range of densities normally seen in healthy humans , leaving causality a very open question.
In both cases, the MDMA exposed group did not show persistently reduced or abnormal regional or total cerebral blood flow. Once the drug has taken full effect, hyperactivity and a powerful central analgesic effect is seen, as is an interesting and very strong non-sedating anxiolytic effect. Increased public awareness of MDMA during the Scheduling fight produced an order-of-magnitude increase in usage and availability the year after its initial Emergency Scheduling.
Cerebral blood flow measurements of users have also been done, both retrospectively  and prospectively  on human volunteers. Levels of the stereoisomers of MDMA and metabolically formed MDA in plasma after the administration of a single 40 mg dose to adult male humans.
One of the interesting consequences of oxidation as the ultimate mechanism of damage is that antioxidants are experimentally very effective in reducing or preventing MDMA neurotoxicity, even at near-lethal doses of MDMA. The Morgue.
To that end, the DEA appointed a case law judge to examine the scientific evidence and give a recommendation on Scheduling. The first is that this drug clearly has the potential to cause extensive destruction of serotonin axons at some high dosage under the right circumstances.
Deaths in the absence of aggravating factors simple overdose are all but unheard of.
There have also been a small number of reports of rectal administration. Thus, the dependent user can both be maintained and discouraged from further use with relatively safe, well understood medications. At higher doses, MDMA produces remarkably dilated but still light-responsive pupils. The most sensationalistic and controversial issue regarding MDMA is claims of neurotoxicity in humans.