Figure 2. The action potential begins at the end of the axon that is attached to the soma and travels down toward the terminal buttons. Biological Bulletin 187: What makes up a neuron?
Nature 406: Journal of Neuroscience 12: Mulkey RM and Zucker RS 1992 Posttetanic potentiation at the crayfish neuromuscular junction is dependent on both intracellular calcium and sodium ion accumulation. So this is the way the information contained in the frequency and duration of a train of action potentials is converted into the amount and duration of neurotransmitter present in the synaptic cleft and that information is passed on to the target cell by a neurotransmitter binding to the receptors and the number of receptors that binds to and the duration of time the neurotransmitter is bound to receptors is related to the amount and the duration of neurotransmitter in the synaptic cleft.
In an intact brain, the balance of hundreds of excitatory and inhibitory inputs to a neuron determines whether an action potential will result. Neurotransmitter removal. Biophysical Journal 33: Up Next. Journal of Physiology London 193: Key facts: At the junction between two neurons synapse , an action potential causes neuron A to release a chemical neurotransmitter.
Jacobs, A. Llinas RR 1989 Calcium in synaptic transmission.
Neurotransmitters Ion Channels. Spafford JD and Zamponi GW 2003 Functional interactions between presynaptic calcium channels and the neurotrasmitter release machinery.
Now, recall we talked about the information contained in action potentials is really contained in the frequency and the duration of a train or a series of action potentials being fired down the axon of the neuron. Katz B and Miledi R 1967a Ionic requirements of synaptic transmitter release.
Molecular Cell Biology 3: All rights reserved. Journal of Neuroscience 23: The entry of positively-charged ions into the cell actually reverses the electrical potential from a negative potential to a positive one, i.
Katz B and Miledi R 1967b A study of synaptic transmission in the absence of nerve impulses. What is deep-brain stimulation?
Jou'l of Experimental Biology 208: Current time: